Top 5 Best Nootropics 2018 (Number 1 Is Essential)

This year has been a great year for nootropics. We’ve had an increase in awareness and more information is posted on the web each day.

Let’s give some credit where it’s due; to all of you who are involved in the fantastic world of nootropics.

We can expect nootropics to reach and help even more people next year. Given the circumstances of our daily life today, we need it more than ever before.

Now, it’s time to compile a list of our top 5 best nootropics of this year. Prepare to have your socks blown off.

1. Lion’s Mane

Is Asia always ahead of us with natural medicine? I think so. This is the number 1 nootropic of 2018.

Lion’s Mane has changed the game with its potency and effect. You cannot go through 2018 without knowing about this fantastic nootropic.

We should learn even more from this region. Given how good the effects of Lion’s Mane are, I have to give it the 1st place. Hopefully, more people in other regions of the world will reap the benefits of this mushroom.

What is it?

Lion’s Mane is a mushroom from Asia. In the Asian region, this mushroom is used in food, medicine and even as a tea.

You can usually buy this as an extract but if you happen to live in Asia, you could pick these up at the markets.

However, the extract works just as well if not better since it’s more concentrated. The mushrooms themselves look like the mane of a lion and gives benefits to your heart and brain.

Benefits

  • Protects your heart

Heart diseases are a big thing today. With high cholesterol and obesity being common health problems that cause blood clots, we need to look out for our heart.

Studies made on rodents have found that Lion’s Mane increases fat metabolism.

Increasing this metabolism will decrease the risk of getting blood clots. The mushroom contains Hericenone B which is a compound that also decreases the rate of blood clotting.

  • Reduced anxiety

The mushroom has an anti-inflammatory effect. A study on mice has shown that this effect reduces stress and anxiety. There is not much research made on humans yet to truly prove this effect, but the effect on mice has been very good.

  • Prevent Dementia and Alzheimer’s

Lion’s Mane contains two compounds called hericenones and erinacines. These compounds help the growth of brain cells. At old age, the brain can have a hard time making connections between thoughts, events and also keeping memories.

Growth of brain cells is a good prevention of this happening. There have also been studies on mice, where the mice who have had Lion’s Mane have reduces the symptoms of memory loss, which is a typical attribute to the disease Alzheimer’s.

On older humans, a study was made to see what happened if they digested 3 grams of Lion’s Mane daily. The result was that the elderly who was in the study showed a great increase in mental capacity, the results stopped when they stopped eating the mushroom daily.

Side effects

  • None

This mushroom is all healthy and natural.

Conclusion – Where to buy

An essential mushroom with a great capacity as a nootropic. My favorite of 2018. Gives benefits to both mental capacity and the health of your heart. Interesting studies and research has shown great results for humans and rodents.

The increase in brain cell growth is significant and is what makes Lion’s Mane take the first place this year. If you’re looking to beat brain fog, this is the only nootropic you need.

You can buy the best Lion’s Mane Mushroom Powder from Nootropicsdepot.

You should try Lion’s Mane out yourself. It’s already used daily in Asia in many dishes and as a medicine, let’s welcome it into our culture as well.

2. Qualia

Known for its superb effect to increase brain performance, cognitive enhancement and more. The general consensus of people who have tried Qualia has been outstanding, even giving it nicknames such as “the God pill”.

People have been talking about Qualia a lot this year and for good reason, it’s time you find out why for yourself.

What is it?

Simply put, Qualia is a nootropic supplement that increases brain performance and general health.

The ingredients of Qualia is a jaw-dropping list of essential vitamins and fantastic nootropic compounds.

A great selection of ingredients that all promote brain health and performance makes this a stack of wonders.

So let’s get into it, what’s inside?

Ingredients

Vitamins for brain performance

  • Vitamin B12 as Methylcobalamin
  • Vitamin C as Ascorbic Acid
  • Vitamin B3 as Niacinamide
  • Vitamin D3 as Microencapsulated Cholecalciferol
  • Vitamin B1 as Benfotiamine
  • Vitamin B6 as Pyridoxal-5-Phosphate
  • Vitamin B5 as Calcium Pantothenate

Nootropic compounds promoting  memory and cognitive function

  • Huperzine A
  • Theobromine
  • Noopept
  • Phenylethylamine
  • Hordenine HCI
  • Vinpocetine
  • Uridine Monophosphate
  • Pterostilbene bound to Caffeine
  • Phosphatidylserine

Natural herbs for better memory and reduced stress

  • Lion’s Mane
  • Bacopa Monnieri
  • Artichoke Extract
  • Mucuna Pruriens
  • Ginkgo Biloba
  • Rhodiola Rosea
  • ActivAMP Gynostemma
  • Coleus Forskohlii

Antioxidants and Anti Inflammatories for the brain

  • Green Tea Extract
  • Algal DHA
  • Curcumin
  • Bioperine
  • Quercetin
  • BioPQQ

Amino Acids

  • L-Theanine
  • Taurine
  • N-Acetyl Tyrosine
  • Acetyl-L-Carnitine
  • DL-Phenylalanine

Essential Minerals

  • Magnesium Threonate
  • Zinc Picolinate
  • Lithium Orotate

Choline Donors

  • Alpha GPC
  • Citicoline
  • Centrophenoxine

Conclusion

Looking at that list of ingredients really opens your eyes to how great Qualia is. It’s essential if you want to have all the best benefits of nootropics and vitamins.

The benefits include better memory, improved brain performance, better health, prevention of diseases that come with old age, stress reduction, increased focus and many more.

Taking this nootropic stack daily will increase your mental capacity and health greatly and is highly recommended for everyone.

If you want a full list of all the benefits of every ingredient in this amazing nootropic stack and their effect, check these articles out, from Neurohacker: Vitamins, Nootropic Compounds, Herbs (Adaptogen Extracts), Amino Acids, Neuro-Minerals, and Choline Donors.

3. Modafinil

The number 3 of the best nootropics of 2018. Modafinil is a potent nootropic that has received a lot of praise this year.

What is it?

Modafinil was developed in the 1970s as an alternative to amphetamine. Today it’s prescribed to many people with narcolepsy and ADHD and works wonders to help treatment.

It’s also used by many people who want to enhance their cognition. So what does it do for you if you don’t have ADHD or narcolepsy? Well, this potent nootropic is actually great for anyone. Let’s get into the benefits.

Benefits

  • Wakefulness

Stay alert and fully awake for the entire day. The effect of Modafinil lasts for around 10 hours, so make sure you take this in the morning.

  • Improved cognition

Research has shown that Modafinil upregulates serotonin, glutamate, histamine levels and orexin. This has been tested on healthy adults who are not suffering from sleep deprivation.

  • Protects your brain

Fairly new research has given a new aspect to Modafinil, the protection from brain damage and sleep induction. Free radicals have shown to be related to cellular damage and sleep induction, these effects will be opposed by Modafinil, this is what gives it the neuroprotective properties.

  • Focus

Modafinil helps the attention. You’ll stay focused for longer and much easier. Study better, work harder and get things done faster.

  • Impulse Control

Other research was done on patients with alcoholism with good results. Lack of impulse control is often what develops an addiction. The effect of Modafinil helps you take control of your impulse and make more thoughtful decisions.

Side effects

Side effects can come with Modafinil so make sure you take it in the morning and not too often.

  • Headaches

  • Nausea

  • Dry mouth

Conclusion

A great nootropic for anyone. Newer research has brought light to cognitive effects and neuroprotective properties that work on any healthy person. Aside from newer research, the widely discussed other benefits are great as well.

4. Sulbutiamine

What is it?

Sulbutiamine is synthetically made and was first produced in the 60s in Japan. It’s a derivative of thiamine (vitamin b1). When two vitamins b1 molecules are bound together they become Sulbutiamine. In France, it’s used as a dietary supplement and to reduce the effects of fatigue. It increases the thiamine production in the brain.

Benefits

  • Improved mood

Gives you more glutamate and dopamine which makes you happier. Also changes how the glutamate works together with dopamine. The glutamate levels increase in the decision-making region of your brain, making it easier to make decisions.

  • Makes your brain more healthy

Cells die in your brain, this is normal. Sulbutiamine increases the glutathione in the brain which reduces cell deaths.

  • Stronger memory

Promotes a better memory. Studies have shown that Sulbutiamine increases the activity in the hippocampus, this boosts your memory.

  • Increases thiamine levels in the brain

More than any thiamine derivative and thiamine itself, Sulbutiamine is the best at increasing thiamine levels in your brain.

  • Reduced symptoms of depression

A study was made on 40 participants where 70% had reduced symptoms of depression, anxiety, and fatigue.

Side effects

With Sulbutiamine you should stay with doses of under 600mg per day, this way you’re not very likely to have any side effects. With higher dosage, there’s a chance you’ll notice side effects such as euphoria and sleep pattern disturbance.

  • Headaches

  • Mild allergies and agitation (if you’re elderly)

Conclusion

A nootropic for improving your mood and memory. There is a lot of anecdotal evidence on the web, of increased and decreased effects of both the benefits and side effects.

Make sure you stick to 600mg per day and not more to stay safe. In moderation, this nootropic is great for promoting its benefits and to be included on this list because of it.

Personally, I’ve had great effect using this nootropic and I think anyone who’s into nootropics should try it out.

 

5. L-Theanine

What is it?

L-Theanine is an amino acid found in green and black tea. It’s been researched a lot and is used in many good stacks of nootropics, including the number 1 post in this article.

It reliefs anxiety and calms the brain. As a supplement, it can be found in forms such as pills and tablets. The flavor of green tea is characterized by l-theanine, this is what gives green tea that great taste. Gives a very relaxing feeling and a better mood.

Benefits

  • Promotes cognitive function

L-theanine’s ability as a nootropic is great. Studies have shown that it has an impact on maintaining and improving cognitive function.

  • Reduces stress

Stress has a very negative impact on your body and mind. You make worse decisions while you’re stressed. L-theanine reduces the stress levels and makes you more tolerant to stress.

Other stress-reducing supplements might make you drowsy. With l-theanine, you do not get drowsy. It’s a natural calm that works wonders for your mind.

  • Improve your immune system

Get sick less with an improved immune system. Your immune system will protect you from all types of viruses, infections, and bacteria. L-theanine has been shown in studies to help for upper respiratory tract infections.

  • Boost your focus

Caffeine is great for your focus and works even better paired with l-theanine, a study has shown. Focus is important to have every day and so is l-theanine. Pair a daily dose of l-theanine with your coffee and you’ll feel the effects in around 30 minutes.

  • Cancer treatment

A study has shown that certain chemotherapy drugs, paired with l-theanine from the Bay Bolete mushroom, improve the effect of chemotherapy. The researches think that l-theanine can improve the treatment.

  • Can be good for sleep

Other research says that l-theanine can help you sleep better at night. This is not completely proven but the group study from 2011 showed that the part of the group who had been given l-theanine had more restful and longer sleep.

Side effects

L-theanine has no real side effects to it with normal usage. It’s an amino acid that’s very good for you. But in higher doses, you could have minor side effects such as:

  • Nausea

  • Upset stomach

If you take a normal dose it’s highly unlikely that you will have any of these side effects.

Conclusion

A fantastic amino-acid that has numerous nootropic effects to improve cognitive ability. If you’re having a hard time falling asleep, giving this a try could help you. The calming and stress-reducing effect is the icing of the cake. Recommended for everyone.

 

Want to find the best nootropics vendors on the market? Find them here.

 

References

Effect of modafinil on impulsivity and relapse in alcohol dependent patients: a randomized, placebo-controlled trial.

Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review.

Mechanisms of modafinil: A review of current research.

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Neural plasticity in the aging brain.

Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice.

The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model

Retention in the body of various O-acyl-thiamine disulfides and several properties of O-butyryl-thiamine disulfide.

Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.

Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.

Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.

Sulphur antioxidants inhibit oxidative stress induced retinal ganglion cell death by scavenging reactive oxygen species but influence nuclear factor (erythroid-derived 2)-like 2 signalling pathway differently.

Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells.

Injection of sulbutiamine induces an increase in thiamine triphosphate in rat tissues.

Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation.

[Use of enerion in psychovegetative syndrome with pronounced asthenia].

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[Facilitation of a state of wakefulness by semi-chronic treatment with sulbutiamin (Arcalion) in Macaca mulatta].

Tian X, Sun L, Gou L, et al. Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain Res. 2013;1503:24-32.

Hugon J, Vallat JM, Dumas M. Role of glutamate and excitotoxicity in neurologic diseases. Rev Neurol (Paris). 1996;152(4):239-48.

Di X, Yan J, Zhao Y, et al. L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. Neuroscience.

Cho HS, Kim S, Lee SY, et al. Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology. 2008;29(4):656-62.

Recent developments in mushrooms as anti-cancer therapeutics: a review

l-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion

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